基本信息:
- 专利标题： Novel acylglutamyl lysine derivative
- 专利标题（中）：新型ACYLGLUTAMYL LYSINE DERIVATIVE
- 申请号：JP2040883 申请日：1983-02-08
- 公开(公告)号：JPS59148745A 公开(公告)日：1984-08-25
- 发明人： KURODA YOSHIO , IGUCHI HIDEKO , KOUSAKA MASANOBU , AOKI HATSUO , IMANAKA HIROSHI , KITAURA YOSHIHIKO , NAKAGUCHI OSAMU , HENMI KEIJI , ARAYA MATSUHIKO , TAKENO SHIYUUICHI , OKADA TATSU , TANAKA HIROKAZU , HASHIMOTO SHINJI
- 申请人： Fujisawa Pharmaceut Co Ltd
- 专利权人： Fujisawa Pharmaceut Co Ltd
- 当前专利权人： Fujisawa Pharmaceut Co Ltd
- 优先权： JP2040883 1983-02-08
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P31/04 ; A61P37/04 ; C07K5/02
摘要：
NEW MATERIAL:An acylglutamyl lysine derivative shown by the formula I (R
1 is palmitoyl, or behenoyl; R
2 is H, or benzyl; R
3 is H, or benzyloxycarbonyl) and its salt.
EXAMPLE: Behenoyl-γ-D-Glu(α-OH)-L-Lys-D-AlaOH.
USE: Having improved preventing effect on infectious diseases and useful as a drug. Useful as a remedy for infectious diseases caused by pathogenic bacteria, especially by Gram-negative, Gram-positive bacteria and molds.
PREPARATION: A compound shown by the formula II is directly reacted with a compound shown by the formula III in the presence of a condensation agent such as N,N-dicyclohexylcarbodiimide, etc., to give a compound shown by the formula I . The compound shown by the formula II and the compound shown by the formula III are novel compounds, the compound shown by the formula II is synthesized from a compound shown by the formula IV and a compound shown by the formula V, and the compound shown by the formula III from the compound shown by the formula IV and a compound shown by the formula VI.
COPYRIGHT: (C)1984,JPO&Japio
摘要（中）：
1 is palmitoyl, or behenoyl; R
2 is H, or benzyl; R
3 is H, or benzyloxycarbonyl) and its salt.
EXAMPLE: Behenoyl-γ-D-Glu(α-OH)-L-Lys-D-AlaOH.
USE: Having improved preventing effect on infectious diseases and useful as a drug. Useful as a remedy for infectious diseases caused by pathogenic bacteria, especially by Gram-negative, Gram-positive bacteria and molds.
PREPARATION: A compound shown by the formula II is directly reacted with a compound shown by the formula III in the presence of a condensation agent such as N,N-dicyclohexylcarbodiimide, etc., to give a compound shown by the formula I . The compound shown by the formula II and the compound shown by the formula III are novel compounds, the compound shown by the formula II is synthesized from a compound shown by the formula IV and a compound shown by the formula V, and the compound shown by the formula III from the compound shown by the formula IV and a compound shown by the formula VI.
COPYRIGHT: (C)1984,JPO&Japio
新物质：由式I表示的酰基谷氨酰赖氨酸衍生物（R 1为棕榈酰基或山嵛酰基; R 2为H或苄基; R 3为H或苄氧基羰基）及其盐。 实施例：山嵛酰-γ-D-GLU（α-OH）-L-赖氨酸D-AlaOH。 用途：改善对传染病的预防作用，有益于药物。 可用作病原菌引起的感染性疾病的补救措施，特别是革兰氏阴性，革兰氏阳性菌和霉菌。 制备：式II化合物在缩合剂例如N，N-二环己基碳二亚胺等存在下，与式Ⅲ化合物直接反应，得到式Ⅰ所示的化合物。 由式II表示的化合物和由式III表示的化合物是新化合物，由式IV所示的化合物和式V所示的化合物合成式II所示的化合物， 由式IV表示的化合物的式III化合物和式VI所示的化合物。
公开/授权文献:
- JPH068313B2 公开/授权日：1994-02-02
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |