基本信息:
- 专利标题： Fluoromethylthiooxacephalosporin
- 专利标题（中）：FLUOROMETHYLTHIOOXACEPHALOSPORIN
- 申请号：JP23447282 申请日：1982-12-23
- 公开(公告)号：JPS59139385A 公开(公告)日：1984-08-10
- 发明人： TSUJI SHIYOUJI , SATOU HISAO , HAMASHIMA YOSHIO
- 申请人： Shionogi & Co Ltd
- 专利权人： Shionogi & Co Ltd
- 当前专利权人： Shionogi & Co Ltd
- 优先权： JP23447282 1982-12-23
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/535 ; A61P31/04 ; C07D505/00
摘要：
NEW MATERIAL:A 7β-(fluorinated methylthioacetamido)-7α-methoxy-3-(1-hydroxyalkyl-5-tetrazolyl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid shown by the formula I [R is FCH
2 -, F
2 CH-; R
1 is R
3 O-substituted alkyl (R
3 is H, or OH-protecting group); R
2 is H, light metal, or carboxyl group], or a derivative at its carboxyl or hydroxalkyl group.
EXAMPLE: 7β-[Difluoromethylthioacetamido-7α-methoxy-3-( 1-benzyloxycarbonyloxyethyl-5-tetrazolyl )thiomethyl]-1-dethia-1-oxa-3-cephem-4-carboxylic acid diphenylmethyl ester.
USE: An antibacterial agent.
PROCESS: An amine(reactive derivative) shown by the formula II is reacted with a methylthioacetic acid fluoride (reactive derivative) shown by the formula RSCH
2 COOH.
COPYRIGHT: (C)1984,JPO&Japio
摘要（中）：
2 -, F
2 CH-; R
1 is R
3 O-substituted alkyl (R
3 is H, or OH-protecting group); R
2 is H, light metal, or carboxyl group], or a derivative at its carboxyl or hydroxalkyl group.
EXAMPLE: 7β-[Difluoromethylthioacetamido-7α-methoxy-3-( 1-benzyloxycarbonyloxyethyl-5-tetrazolyl )thiomethyl]-1-dethia-1-oxa-3-cephem-4-carboxylic acid diphenylmethyl ester.
USE: An antibacterial agent.
PROCESS: An amine(reactive derivative) shown by the formula II is reacted with a methylthioacetic acid fluoride (reactive derivative) shown by the formula RSCH
2 COOH.
COPYRIGHT: (C)1984,JPO&Japio
新材料：式I所示的7a-（氟化甲硫基乙酰氨基）-7α-甲氧基-3-（1-羟基烷基-5-四唑基）甲基-1-脱硫-1-氧杂-3-头孢烯-4-羧酸 [R是FCH 2 - ，F 2 CH-; R 1是R 3 O-取代的烷基（R 3是H或OH保护基）; R 2是H，轻金属或羧基]或其羧基或羟烷基上的衍生物。 实施例：7beta- [二氟甲硫基乙酰氨基-7α-甲氧基-3-（1-苄氧羰基氧基乙基-5-四唑基）硫甲基] -1-脱硫-1-氧杂-3-头孢烯-4-羧酸二苯基甲酯。 用途：抗菌剂。 方法：由式II所示的胺（反应性衍生物）与式RSCH 2 COOH所示的甲硫基乙酸氟化物（反应性衍生物）反应。
公开/授权文献:
- JPS6225671B2 公开/授权日：1987-06-04
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D498/00 | 杂环化合物，在稠环系中至少有1个杂环具有氮和氧原子作为仅有的杂环原子 |
| --------C07D498/02 | .在稠环系中含有两个杂环 |
| ----------C07D498/04 | ..邻位稠合系 |