基本信息:
- 专利标题： 4,8-dimethylbicyclo(3.3.1)nonan-2-ol derivative
- 专利标题（中）：4,3-二甲基苯酚（3.3.1）NONAN-2-OL DERIVATIVE
- 申请号：JP22325882 申请日：1982-12-20
- 公开(公告)号：JPS59112933A 公开(公告)日：1984-06-29
- 发明人： TAKEDA MAKOTO , IWANE HIROSHI , YOSHIDA AKIRA , MORI TERUO
- 申请人： Mitsubishi Petrochem Co Ltd
- 专利权人： Mitsubishi Petrochem Co Ltd
- 当前专利权人： Mitsubishi Petrochem Co Ltd
- 优先权： JP22325882 1982-12-20
- 主分类号： C07C35/27
- IPC分类号： C07C35/27 ; A61K8/34 ; A61Q13/00 ; C07C27/00 ; C07C35/23 ; C07C43/18 ; C07C43/188 ; C07C45/29 ; C07C49/443 ; C07C49/633 ; C07C67/00 ; C11B9/00
摘要：
NEW MATERIAL:The titled compound of formula I .
EXAMPLE: (1R,2R,5R)-4,8-Dimethylbicyclo[3.3.1]nonan-7-en-2-ol.
USE: A perfumery substance having strong menthol-like smell, and expected to be useful as perfumery.
PROCESS: 3-(4-Methyl-3-cyclohexenyl)butylaldehyde of formula II is made to react preferably in a solvent in the presence of an acid catalyst at 0W100°C to effect the intramolecular cyclization and obtain 4,8-dimethylbicyclo[3.3.1]nonan-7-en- 2-ol of formula I wherein the dotted line is double bond. The double bond in the ring is catalytically hydrogenated preferably in a solvent, in the presence of a catalyst such as Pd/C at 0W150°C under hydrogen pressure of 0W5 atm to obtain 4,8-dimethylbicyclo[3.3.1]nonan-2-ol of formula I wherein the dotted line is single bond.
COPYRIGHT: (C)1984,JPO&Japio
摘要（中）：
EXAMPLE: (1R,2R,5R)-4,8-Dimethylbicyclo[3.3.1]nonan-7-en-2-ol.
USE: A perfumery substance having strong menthol-like smell, and expected to be useful as perfumery.
PROCESS: 3-(4-Methyl-3-cyclohexenyl)butylaldehyde of formula II is made to react preferably in a solvent in the presence of an acid catalyst at 0W100°C to effect the intramolecular cyclization and obtain 4,8-dimethylbicyclo[3.3.1]nonan-7-en- 2-ol of formula I wherein the dotted line is double bond. The double bond in the ring is catalytically hydrogenated preferably in a solvent, in the presence of a catalyst such as Pd/C at 0W150°C under hydrogen pressure of 0W5 atm to obtain 4,8-dimethylbicyclo[3.3.1]nonan-2-ol of formula I wherein the dotted line is single bond.
COPYRIGHT: (C)1984,JPO&Japio
新材料：式I的标题化合物。 实施例：（1R，2R，5R）-4,8-二甲基二环[3.3.1]壬-7-烯-2-醇。 用途：具有强烈薄荷醇样气味的香料，预计作为香料有用。 方法：使式II的3-（4-甲基-3-环己烯基）丁醛在0-100℃下在酸催化剂存在下，优选在溶剂中进行反应，以实现分子内环化，得到4,8- 二甲基二环[3.3.1]壬烷-7-烯-2-醇，其中虚线是双键。 优选在溶剂中，在0-150℃的催化剂例如Pd / C的存在下，在0-5atm的氢气压力下，环中的双键进行催化氢化，得到4,8-二甲基双环[3.3.2。 1]壬-2-醇，其中虚线是单键。
公开/授权文献:
- JPH0340014B2 公开/授权日：1991-06-17
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C33/00 | 非环碳原子上连接羟基或氧—金属基的不饱和化合物 |
| --------C07C35/22 | .多环醇，在稠合环上至少连接1个羟基的 |
| ----------C07C35/23 | ..羟基连接在双环稠环体系上 |
| ------------C07C35/27 | ...含6个碳原子的稠环体系 |