基本信息:
- 专利标题： 1,4-DIHYDROPYRIDNE COMPOUND
- 申请号：JP2679082 申请日：1982-02-23
- 公开(公告)号：JPS58159490A 公开(公告)日：1983-09-21
- 发明人： INOUE YOUICHI , MATSUMOTO TOSHIO , NIWA HIROSUKE , SUZUKI KENICHI , HOSHIIDE YASUO
- 申请人： NIKKEN CHEMICALS CO LTD , INST ORUGANIICHIESUKAGO SHINTE
- 专利权人： NIKKEN CHEMICALS CO LTD,INST ORUGANIICHIESUKAGO SHINTE
- 当前专利权人： NIKKEN CHEMICALS CO LTD,INST ORUGANIICHIESUKAGO SHINTE
- 优先权： JP2679082 1982-02-23
- 主分类号： C07D405/04
- IPC分类号： C07D405/04 ; A61K31/44 ; A61K31/443 ; A61K31/455 ; A61P1/16 ; C07D407/04
摘要：
NEW MATERIAL:A compound shown by the formulaI(R and R' are methyl, ethyl or propyl). EXAMPLE:3,5-Diethoxycarbonyl-4-[2'-(5',6'-dihydro-p-dioxynyl)]-2,6-dim ethyl-1,4- dihydropyridine. USE:Effective for remedying and preventing hepatic disorders induced by D-galactosamine, CCl4, etc. A useful compound having improved protecting action on the liver, low toxicity, to be expected as a remedy for hepatic diseases. PROCESS:2-Formyl-p-dioxene shown by the formula II is reacted with an acetoacetic acid lower alkyl ester shown by the formula III and a beta-aminocrotonic acid lower alkyl ester shown by the formula IV in the presence or absence of an organic solvent under heating, to give a compound shown by the formulaI.
公开/授权文献:
- JPH0129794B2 公开/授权日：1989-06-14
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D405/00 | 杂环化合物，含有1个或多个以氧原子作为仅有的杂环原子的环，且含有1个或多个以氮原子作为仅有的杂环原子的环 |
| --------C07D405/02 | .含有两个杂环 |
| ----------C07D405/04 | ..被环原子—环原子的键直接连接的 |