发明专利
JPS5463024A 33*NNFORMYLLNNHYDROXYAMINO**2*R**HYDROXYPROPYLLPHOSPHONIC ACID* ITS PREPARATION* AND ITS USE
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基本信息:
- 专利标题： 33*NNFORMYLLNNHYDROXYAMINO**2*R**HYDROXYPROPYLLPHOSPHONIC ACID* ITS PREPARATION* AND ITS USE
- 申请号：JP12933777 申请日：1977-10-27
- 公开(公告)号：JPS5463024A 公开(公告)日：1979-05-21
- 发明人： KAMIYA TAKASHI , HASHIMOTO SHINJI , HENMI KEIJI , TAKENO SHIYUUICHI
- 申请人： FUJISAWA PHARMACEUTICAL CO
- 专利权人： FUJISAWA PHARMACEUTICAL CO
- 当前专利权人： FUJISAWA PHARMACEUTICAL CO
- 优先权： JP12933777 1977-10-27
- 主分类号： C07F9/38
- IPC分类号： C07F9/38 ; A61K31/66 ; A61P31/04 ; C07F9/40
摘要：
NEW MATERIAL:3-(N-Formyl-N-hydroxyamino)-2(R)-hydroxypropylphonic acid of formula I and its salts. USE:A preventive and a remedy for bacterially infected diseases. PROCESS:For example, diethyl 2(R), 3-dihydroxyprophylphosphonate is made to react with a reaction reagnet of formula R SO3H (R =alkyl or aryl), e.g. p-toluene sulphonic acid chloride, or its reactive derivative. The reaction product obtained is then made to react with an OH-protecting agent and a compound of formula II (R are protecting proup of hydroxy and amino groups), e.g. N,O-bis (trimethylsilyl) acetamide to give a compound of formula III (R =H or hdroxy protecting goup), which is successively subjected to the hydrolysis and the formylation to afford the objective compound.
公开/授权文献:
- JPS5456372U 公开/授权日：1979-04-18
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07F | 含除碳、氢、卤素、氧、氮、硫、硒或碲以外的其他元素的无环，碳环或杂环化合物 |
| ------C07F9/00 | 含周期表第Ⅴ族元素的化合物 |
| --------C07F9/02 | .磷化合物 |
| ----------C07F9/06 | ..无P—C键的 |
| ------------C07F9/38 | ...膦酸；硫代膦酸 |