基本信息:
- 专利标题： FLUORINATED VITAMIN D3 ANALOGUE
- 申请号：JP12923897 申请日：1997-05-20
- 公开(公告)号：JPH1045712A 公开(公告)日：1998-02-17
- 发明人： HENNESSY BERNARD MICHAEL , USKOKOVIC MILAN RADOJE
- 申请人： HOFFMANN LA ROCHE
- 专利权人： HOFFMANN LA ROCHE
- 当前专利权人： HOFFMANN LA ROCHE
- 优先权： US1818796 1996-05-23
- 主分类号： A61K31/59
- IPC分类号： A61K31/59 ; A61P3/02 ; A61P17/00 ; A61P35/00 ; A61P43/00 ; C07C401/00
摘要：
PROBLEM TO BE SOLVED: To obtain the subject new compound useful for treating hypertrophic diseases, neoplastic diseases and sebaceous gland diseases by inducing the differentiation and suppression of proliferation of various ski cell systems and cancer cell systems. SOLUTION: This 16-ene-23-yn-trifluoro analogue of vitamin D3 is represented by tehformula (R is H, F or hydroxy; X is CH2 or H), e.g. [3aS,[(1S*,3aα,7α,7 aβ]]-1,1,1-trifluoro-6-[3a,4,5,6,7,7a-hexahydro-3a-methyl-7-[(trimethyls ilyl)oxy-1H- inden-3-yl]-2-methyl-3-heptyn-2-ol (epimer). The compound represented by the formula is formulated together with a pharmacologically insert inorganic or organic vehicle to provide a medicinal composition.
公开/授权文献:
- JP2858571B2 公开/授权日：1999-02-17
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/59 | .含9,10开环环戊a氢化菲环系的化合物 |