基本信息:
- 专利标题： TRICYCLIC COMPOUND
- 申请号：JP7558792 申请日：1992-02-27
- 公开(公告)号：JPH0578292A 公开(公告)日：1993-03-30
- 发明人： SAWANISHI HIROYUKI , ITO YASUO , KATO HIDEO , ECCHU EIICHI , OGAWA NOBUO , MORIKAWA KOJI
- 申请人： HOKURIKU PHARMACEUTICAL
- 专利权人： HOKURIKU PHARMACEUTICAL
- 当前专利权人： HOKURIKU PHARMACEUTICAL
- 优先权： JP7558792 1992-02-27; JP9977591 1991-04-05; JP14410791 1991-05-21
- 主分类号： A61K31/195
- IPC分类号： A61K31/195 ; A61K31/335 ; A61K31/35 ; A61K31/352 ; A61P37/08 ; A61P43/00 ; C07C229/14 ; C07D311/80 ; C07D311/82 ; C07D313/12 ; C07D313/14
摘要：
PURPOSE:To provide a new tricyclic compound useful as an anti-histaminic agent or anti-allergic agent reduced in the side effects and having excellent selectivity. CONSTITUTION:A tricyclic compound of formula I (X is CH=CH, CH2O, O; R is lower alkyl; R is H, lower alkyl; (n) is 1-5) and its salt. For example, [N-[3-(5H-benzo[a,b]cyclophepten-5-ylidene)prpyl]-N-methylamino]acetic acid ethyl ester. The compound is obtained by reacting a compound of formula II with a compound of formula III or IV (Y is halogen) at 0-200 deg.C and, if necessary, hydrolyzing the reaction product with an acid or base in a solvent. The raw material of formula II includes 5-[3-(methylamino)propylindene]-5H- dibenzo[a,b]cycloheptene.
公开/授权文献:
- JPH0641115U 公开/授权日：1994-05-31
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/19 | ..羧酸；例如丙戊酸 |
| ------------A61K31/195 | ...含氨基的 |