基本信息:
- 专利标题： N-SUBSTITUTED ACYLAMINO ACID DERIVATIVE
- 申请号：JP32518289 申请日：1989-12-15
- 公开(公告)号：JPH037255A 公开(公告)日：1991-01-14
- 发明人： MORISHIMA HAJIME , KOIKE TAKASHI , NAKANO MASATO , ATSUMI SHUGO , TANAKA SEIICHI , MATSUYAMA KENJI
- 申请人： BANYU PHARMA CO LTD
- 专利权人： BANYU PHARMA CO LTD
- 当前专利权人： BANYU PHARMA CO LTD
- 优先权： JP32009688 1988-12-19; JP6892189 1989-03-20
- 主分类号： A61K38/55
- IPC分类号： A61K38/55 ; A61K31/22 ; A61K31/221 ; A61K31/223 ; A61K31/535 ; A61K31/5375 ; A61K31/5377 ; A61P9/12 ; C07C59/48 ; C07C317/44 ; C07C323/41 ; C07C323/60 ; C07D233/54 ; C07D277/30 ; C07D295/12 ; C07D295/125 ; C07D401/12 ; C07H15/14 ; C07H15/26 ; C07K5/06
摘要：
NEW MATERIAL:A compound expressed by formula I [R is substituted 1-6C alkyl, 3-7C cycloalkyl, etc.; R , R and R are H, 1-6C alkyl, 3-7C cycloalkyl, 6-10C aryl, etc.; R and R are H or 1-6C alkyl; A is -CH(OH)-(CH2)9-R (R is H, 1-6C alkyl, etc.; q is 0-5), etc.; m is 0-2; n is 1-5] or salt thereof. EXAMPLE:(2S,3R,4S)-{L-N-[(2S)-3-[(2RS)-2,3-diacetoxypropyl]sulfonyl-2-(1- naphthylmethyl)propionyl]norleucyl}amino-5-cyclohexyl-1-morpholino-2,3- pentanediol. USE:A hypotensive agent capable of exhibiting renin inhibitory action and oral absorbability. PREPARATION:A compound expressed by formula II or reactive derivative at the carboxyl group thereof and a compound expressed by formula III are subjected to condensing reaction to afford the compound expressed by formula I.
公开/授权文献:
- JP2943191B2 N-SUBSTITUTED ACYLAMINO ACID DERIVATIVE 公开/授权日：1999-08-30
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/04 | .在完全确定的序列中最多有20个氨基酸的肽；其衍生物 |
| ----------A61K38/55 | ..蛋白酶抑制剂 |