基本信息:
- 专利标题： QUINOLONECARBOXYLIC ACID DERIVATIVE
- 申请号：JP5880989 申请日：1989-03-10
- 公开(公告)号：JPH0276875A 公开(公告)日：1990-03-16
- 发明人： TSUJI SHOJI , SATO HISAO , OKADA TETSUO
- 申请人： SHIONOGI & CO
- 专利权人： SHIONOGI & CO
- 当前专利权人： SHIONOGI & CO
- 优先权： JP5880989 1989-03-10; JP15259388 1988-06-21
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61P31/04 ; C07D401/04 ; C07D409/14
摘要：
NEW MATERIAL:Compounds represented by formula I [R is lower alkyl; R is H or lower alkyl; R is H or protecting group for amino; R is cyclopropyl, (substituted)phenyl or (substituted)thienyl; R is halogen] or salts thereof. EXAMPLE:1-Cyclopropyl-5-amino-6,8-difluoro-1,4-dihydro-7-(cis-3-methyl amino-4- methoxy-1-pyrolidinyl)-4-oxo-3-quinolinecarboxylic acid. USE:An antibacterial agent having a strong antibiotic action while central side effects such as convulsion are reduced. PREPARATION:For example, a compound of formula II is reacted with an amine of formula III to obtain a compound of formula I.
公开/授权文献:
- JPH0674261B2 公开/授权日：1994-09-21
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/47 | ....喹啉；异喹啉 |