基本信息:
- 专利标题： PRODUCTION OF N-PROTECTED ASPARTIC ACID ANHYDRIDE
- 申请号：JP11040388 申请日：1988-05-09
- 公开(公告)号：JPH01283282A 公开(公告)日：1989-11-14
- 发明人： AJIOKA MASANOBU , OURA TAKESHI , HIGUCHI CHOJIRO , KATO TOSHIO , YAMAGUCHI TERUHIRO
- 申请人： MITSUI TOATSU CHEMICALS
- 专利权人： MITSUI TOATSU CHEMICALS
- 当前专利权人： MITSUI TOATSU CHEMICALS
- 优先权： JP11040388 1988-05-09
- 主分类号： C07D307/66
- IPC分类号： C07D307/66 ; C07B61/00
摘要：
PURPOSE:To obtain the subject compound useful as an intermediate for amino acid esters or peptide synthesis, with simple operation in high yield, by reacting an N-protected aspartic acid with phosgene in an inert organic solvent. CONSTITUTION:The objective anhydride can be produced by reacting an N- protected aspartic acid (e.g., N-benzyloxycarbonyl-L-aspartic acid) with phosgene as a dehydration agent in an inert solvent (e.g., ethyl ether or THF) preferably at 10-60 deg.C.
公开/授权文献:
- JP2688210B2 公开/授权日：1997-12-08
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D307/00 | 杂环化合物，含五元环，含有1个氧原子作为仅有的杂环原子 |
| --------C07D307/02 | .不和其他环稠合 |
| ----------C07D307/04 | ..环原子间或环原子与非环原子间没有双键 |
| ------------C07D307/38 | ...有取代的烃基连在环碳原子上 |
| --------------C07D307/66 | ....氮原子 |