基本信息:
- 专利标题： 1,5-BENZOTHIAZEPIN DERIVATIVE, REMEDY FOR DYSURIA AND ITS PRODUCTION
- 申请号：JP226988 申请日：1988-01-07
- 公开(公告)号：JPH01180880A 公开(公告)日：1989-07-18
- 发明人： TOMIYAMA TAKESHI , TOMIYAMA ITARU , KAMIYAMA NAOTO , WAKABAYASHI SHUICHI
- 申请人： KOTOBUKI SEIYAKU CO LTD
- 专利权人： KOTOBUKI SEIYAKU CO LTD
- 当前专利权人： KOTOBUKI SEIYAKU CO LTD
- 优先权： JP226988 1988-01-07
- 主分类号： C07D281/10
- IPC分类号： C07D281/10 ; A61K31/55 ; A61K31/554 ; A61P3/00 ; A61P3/14 ; A61P13/02 ; A61P15/00 ; A61P25/02
摘要：
NEW MATERIAL:An N-substituted-2,3,4,5-tetrahydro-1,5-benzothiazepin derivative of formula I (R is hydroxyl, lower alkyl, phenyl; R , R are identical or different lower alkyl) and its acid adduct. EXAMPLE:5-{3-[2-(3-Diethylaminophenoxy)ethylamino]propionyl}-2,3,4,5-t etra- hydro-1,5-benzothiazepin. USE:It is used as a remedy for dysuria. It has both calcium-antagonistic and alpha-blocking actions, and shows the selectivity to urethral smooth muscles without side-effect on hypotension. PREPARATION:The reaction of a compound of formula II (A is amino group, halogen) with a compound of formula III (B is halogen or p-toluenesulfonyl, when A is amino group; or amino group, when A is halogen) gives the compound of formula I.
公开/授权文献:
- JP2592276B2 公开/授权日：1997-03-19
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D281/00 | 杂环化合物，含大于六元的环、有1个氮原子和1个硫原子作为仅有的杂环原子 |
| --------C07D281/02 | .七元环 |
| ----------C07D281/04 | ..杂原子在位置1，4上 |
| ------------C07D281/08 | ...和碳环系稠合 |
| --------------C07D281/10 | ....和1个六元环稠合 |