发明专利
JP4063687B2 High-speed automated continuous flow, multi-dimensional molecular sorting and analysis
有权
基本信息:
- 专利标题: High-speed automated continuous flow, multi-dimensional molecular sorting and analysis
- 申请号:JP2003031782 申请日:2003-02-07
- 公开(公告)号:JP4063687B2 公开(公告)日:2008-03-19
- 发明人: ノーバー, ビー. アフェヤン, , ケヴィン ウィリアムズ, , デイヴィッド エヴァンズ, , サティッシュ ジンダル, , サンディープ パリワル, , アルナ ピンガリ, , レグニア,フレッド,イー.
- 申请人: パーセプティブ バイオシステムズ,インコーポレーテッド
- 专利权人: パーセプティブ バイオシステムズ,インコーポレーテッド
- 当前专利权人: パーセプティブ バイオシステムズ,インコーポレーテッド
- 优先权: US51895 1995-06-26
- 主分类号: G01N27/62
- IPC分类号: G01N27/62 ; G01N30/46 ; B01J20/281 ; C12Q1/68 ; C40B20/00 ; C40B30/04 ; C40B40/02 ; C40B50/06 ; C40B60/04 ; G01N27/64 ; G01N30/02 ; G01N30/08 ; G01N30/50 ; G01N30/72 ; G01N30/84 ; G01N30/88 ; G01N33/15 ; G01N33/50 ; G01N33/543 ; G01N33/566
摘要:
The invention provides novel methods for screening a sample to select a ligand to a target of interest and for obtaining information about the ligand and its binding characteristics. Specifically, the claimed multi-dimensional methods involve combining a solution of heterogeneous ligands with the target of interest to screen the ligands on the basis of one or more binding characteristics. Ligands having the first binding characteristic bind to the target of interest thereby to form a target/ligand complex. The complex then optionally is separated from the unbound components using any of a variety of separation techniques, e.g., size exclusion. At least one of the complex or unbound components then is introduced to a second "dimension". The second dimension is capable of separating components based upon a second binding characteristic. One then elutes the ligand having the desired binding characteristics.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
G | 物理 |
--G01 | 测量;测试 |
----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
------G01N27/00 | 用电、电化学或磁的方法测试或分析材料 |
--------G01N27/62 | .通过测试气体的电离,通过测试放电,例如阴极发射 |