基本信息:
- 专利标题： 複数分子の抗原に繰り返し結合する抗原結合分子
- 专利标题（英）：ANTIGEN-BINDING MOLECULE BINDING TO A PLURALITY OF ANTIGEN MOLECULES REPEATEDLY
- 申请号：JP2020169015 申请日：2020-10-06
- 公开(公告)号：JP2021011490A 公开(公告)日：2021-02-04
- 发明人： 井川 智之 , 石井 慎也 , 前田 敦彦 , 中井 貴士
- 申请人： 中外製薬株式会社
- 申请人地址： 東京都北区浮間5丁目5番1号
- 专利权人： 中外製薬株式会社
- 当前专利权人： 中外製薬株式会社
- 当前专利权人地址： 東京都北区浮間5丁目5番1号
- 代理人： 山本 修; 宮前 徹; 松尾 淳一; 寺地 拓己; 一宮 維幸
- 优先权： JP2008104147 2008-04-11 JP2008247713 2008-09-26 JP2009068744 2009-03-19
- 主分类号： C07K1/22
- IPC分类号： C07K1/22 ; A61K39/395 ; G01N33/15 ; G01N33/50 ; C07K16/18
To provide a method for improving the pharmacokinetics of an antigen-binding molecule, a method for increasing the number of times for the antigen-binding molecule to bind to an antigen, an antigen-binding molecule improved in pharmacokinetics, an antigen-binding molecule improved in the number of times for the antigen-binding molecule to bind to an antigen, and methods for producing those.SOLUTION: This antigen-binding molecule has a value of KD(pH 5.8)/KD(pH 7.4), a ratio of KD for the antigen at pH 5.8 to KD for the antigen at pH 7.4, of 2 or more. There is provided a method for improving the pharmacokinetics of an antigen-binding molecule by weakening the antigen-binding activity of the antigen-binding molecule at pH 5.8 as compared to the antigen-binding activity at pH 7.4.SELECTED DRAWING: None