基本信息:
- 专利标题： グライコシンターゼ
- 专利标题（英）：Graphic equalizer synthase
- 专利标题（中）：图形均衡器合酶
- 申请号：JP2016061996 申请日：2016-03-25
- 公开(公告)号：JP2017012152A 公开(公告)日：2017-01-19
- 发明人： 高島 晶 , 天野 純子 , 白井 孝
- 申请人： 公益財団法人野口研究所
- 申请人地址： 東京都板橋区加賀一丁目9番7号
- 专利权人： 公益財団法人野口研究所
- 当前专利权人： 公益財団法人野口研究所
- 当前专利权人地址： 東京都板橋区加賀一丁目9番7号
- 代理人： 特許業務法人たかはし国際特許事務所
- 优先权： JP2015130271 2015-06-29
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N15/00 ; C07K16/00 ; C12N5/10 ; C12N1/21 ; C12N1/15 ; C12N1/19 ; C12P21/08 ; A61K39/395 ; C12N9/10
The present invention relates in graphic equalizer synthase, which can be used in the remodeling of the antibody sugar chain, broad substrate specificity than conventional enzyme, is a highly specific activity enzymes, and to provide a graphic equalizer synthase also show activity in a wider pH range.
A substrate specificity: bound antibody, or "α1,6- bound to the N- acetyl glucosamine to only N- acetyl glucosamine as a sugar component is" glycosylation site present in the Fc region of the antibody " the antibody "in the state which fucose is added to the acceptor substrate, in the reaction system to a variety of sugar chain was a donor substrate, under the conditions of pH4 or more and 10 or less, to efficiently transglycosylation the sugar chains derived from the donor substrate to the acceptor substrate .
.FIELD 7
公开/授权文献:
- JP6744738B2 グライコシンターゼ 公开/授权日：2020-08-19