基本信息:
- 专利标题： ナノ粒子−ペプチド組成物
- 专利标题（英）：Nanoparticle - peptide composition
- 专利标题（中）：纳米颗粒 - 肽组合物
- 申请号：JP2014529001 申请日：2012-09-07
- 公开(公告)号：JP2014527960A 公开(公告)日：2014-10-23
- 发明人： トマス・ラデマッハー , フィリップ・ウィリアムズ
- 申请人： ミダテック リミテッド , ミダテック リミテッド
- 专利权人： ミダテック リミテッド,ミダテック リミテッド
- 当前专利权人： ミダテック リミテッド,ミダテック リミテッド
- 优先权： US201161531745 2011-09-07
- 主分类号： A61K39/385
- IPC分类号： A61K39/385 ; A61K9/06 ; A61K9/16 ; A61K9/70 ; A61K9/72 ; A61K38/00 ; A61K39/00 ; A61K39/002 ; A61K39/02 ; A61K39/12 ; A61K39/39 ; A61K47/00 ; A61K47/02 ; A61P31/04 ; A61P31/12 ; A61P31/22 ; A61P33/00 ; A61P35/00
The present invention relates to compositions comprising nanoparticles and such nanoparticles, and methods for intracellular delivery of peptides, and methods for producing nanoparticles and related products. Nanoparticles, core and containing a metal and / or semiconductor atoms; and a corona comprising a plurality of ligands which are covalently linked to the core, at least a first ligand of the plurality of ligands, the first comprising a carbohydrate moiety covalently linked to the core via a linker, at least a second ligand of the plurality of ligands, the selected peptides are covalently linked to the core via a second linker including. Second linker comprises a peptide moiety and a non-peptide moiety, wherein the peptide portion of the second linker is of the Formula sequence X 1 X 2 Z 1, X 1 is an amino acid selected from A and G There; X-2 is an amino acid selected from a and G; Z 1 comprises an a 'amino acid selected from Y and F.
公开/授权文献:
- JP6077544B2 ナノ粒子−ペプチド組成物 公开/授权日：2017-02-08
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/385 | .半抗原或抗原，连结载体者 |