PROBLEM TO BE SOLVED: To provide a stent capable of delivering a relatively large volume of a beneficial agent to a traumatized site in a vessel, without increasing the effective wall thickness of the stent, and without adversely impacting the mechanical expansion properties of the stent.SOLUTION: An expandable medical device 10 has a plurality of elongated struts 18 joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. The beneficial agent is loaded into the opening within the strut to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles includes zero order, pulsatile, increase, decrease, sinusoidal function, and other delivery profiles.