基本信息:
- 专利标题： Compositions and methods for treating and diagnosing cancer
- 申请号：JP2010514866 申请日：2008-07-02
- 公开(公告)号：JP2010532169A 公开(公告)日：2010-10-07
- 发明人： オースティン ガーニー
- 申请人： オンコメッド ファーマシューティカルズ インコーポレイテッド
- 专利权人： オンコメッド ファーマシューティカルズ インコーポレイテッド
- 当前专利权人： オンコメッド ファーマシューティカルズ インコーポレイテッド
- 优先权： US94761107 2007-07-02
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K39/395 ; A61K45/00 ; A61P35/00 ; C07K14/705 ; C07K16/28 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12P21/08
The present invention characterizes the cancer, to compositions and methods for diagnosing and treatment. In particular, the present invention provides a protein that is overexpressed in solid tumor stem cells, identifies the LGR5. The present invention provides, as another route for the activation of β- catenin signaling, more particularly the interaction between RSPO1 and LGR5. In certain embodiments, the present invention provides a biomolecule disturbing the functional signaling by LGR protein, in certain embodiments, the one or more RSPO protein, one or more LGR like LGR5 It includes molecules that inhibit the interaction between the protein. In certain embodiments, the present invention includes the step of inhibiting the growth of solid tumors, including stage and solid tumor stem cells disrupt the functional LGR signaling, provides a method of treating cancer.
公开/授权文献:
- JP5931336B2 がんを処置および診断するための組成物および方法 公开/授权日：2016-06-08