基本信息:
- 专利标题： Fulvene and fulvalene analogues, and its use in cancer treatment
- 申请号：JP2010506687 申请日：2008-05-02
- 公开(公告)号：JP2010526100A 公开(公告)日：2010-07-29
- 发明人： ジャック エル． アーバイサー
- 申请人： エモリー ユニバーシティ
- 专利权人： エモリー ユニバーシティ
- 当前专利权人： エモリー ユニバーシティ
- 优先权： US92741607 2007-05-03; US93438107 2007-06-13; US4771708 2008-04-24
- 主分类号： C07C13/28
- IPC分类号： C07C13/28 ; A61K31/015 ; A61K31/05 ; A61K31/085 ; A61K31/136 ; A61K31/16 ; A61K31/222 ; A61K31/351 ; A61K31/352 ; A61K31/357 ; A61K31/365 ; A61K31/403 ; A61K31/404 ; A61K31/4164 ; A61K31/42 ; A61K31/426 ; A61K31/444 ; A61K31/5375 ; A61K31/573 ; A61P1/00 ; A61P9/10 ; A61P11/06 ; A61P17/00 ; A61P17/06 ; A61P19/02 ; A61P19/10 ; A61P25/00 ; A61P27/02 ; A61P27/04 ; A61P27/06 ; A61P27/12 ; A61P27/14 ; A61P35/00 ; A61P39/06 ; A61P43/00 ; C07C13/40 ; C07C13/465 ; C07C13/58 ; C07C25/18 ; C07C35/32 ; C07C39/23 ; C07C43/215 ; C07C43/23 ; C07C69/608 ; C07C211/50 ; C07C215/64 ; C07C233/44 ; C07C237/26 ; C07C275/64 ; C07D209/86 ; C07D213/22 ; C07D233/58 ; C07D233/68 ; C07D307/58 ; C07D309/36 ; C07D311/58 ; C07D311/60 ; C07D311/62 ; C07D311/82 ; C07D407/04 ; C07D471/10 ; C07D473/34 ; C07J9/00
摘要：
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, as well as numerous inflammatory, degenerative and vascular diseases, including various ocular diseases. Representative fulvene and/or fulvalene analogs include fulvene and fulvalene analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function, at least, by inhibiting Nox or ROS. In some embodiments, the Nox is one that is selectively expressed in cancer cells over normal cells, or one that is expressed in higher amounts in cancer cells over normal cells. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C13/00 | 含有除六元芳环外的环的环烃，或带有六元芳环的环烃 |
| --------C07C13/28 | .多环烃或其无环烃衍生物 |