基本信息:
- 专利标题： Recombinant human interferon-like protein
- 申请号：JP2009545766 申请日：2007-06-22
- 公开(公告)号：JP2010515466A 公开(公告)日：2010-05-13
- 发明人： ジャン、ルイ , シュー、ジン , ドゥ、ヨン , マオ、チュンション , リ、ジーヂー , リウ、ロンビン , ワン、ハイタオ , ワン、リン
- 申请人： ノバジェン ホールディング コーポレイションNovagen Holding Corporation
- 专利权人： ノバジェン ホールディング コーポレイションNovagen Holding Corporation
- 当前专利权人： ノバジェン ホールディング コーポレイションＮｏｖａｇｅｎ Ｈｏｌｄｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ
- 优先权： US76478607 2007-06-18
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/21 ; A61P1/04 ; A61P1/16 ; A61P11/00 ; A61P13/08 ; A61P15/00 ; A61P17/00 ; A61P31/12 ; A61P35/00 ; A61P35/02 ; A61P37/02 ; C07K14/56 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10
摘要：
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-±2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.