基本信息:
- 专利标题： ANTAGONIST OF GONADOTROPIN RELEASING HORMONE
- 申请号：JP2000257791 申请日：2000-08-28
- 公开(公告)号：JP2001106685A 公开(公告)日：2001-04-17
- 发明人： GOULET MARK , ASHTON WALLACE T , CHU LIN , FISHER MICHAEL H , GIROTRA NARINDAR N , LIN PETER , WYVRATT MATTHEW J
- 申请人： MERCK & CO INC
- 专利权人： MERCK & CO INC
- 当前专利权人： MERCK & CO INC
- 优先权： GB9603242 1996-02-16; US863395 1995-12-14
- 主分类号： A61K31/422
- IPC分类号： A61K31/422 ; A61K31/44 ; A61K31/4427 ; A61K31/4439 ; A61K31/444 ; A61K31/445 ; A61K31/4545 ; A61K31/47 ; A61K31/4709 ; A61K31/4725 ; A61K31/535 ; A61K31/5377 ; A61P1/00 ; A61P1/12 ; A61P5/02 ; A61P5/24 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P15/18 ; A61P17/00 ; A61P25/20 ; A61P25/22 ; A61P35/00 ; A61P37/00 ; A61P43/00 ; C07D401/12 ; C07D401/14 ; C07D413/14 ; C07D471/08 ; C07D487/08
摘要：
PROBLEM TO BE SOLVED: To obtain a medicinal composition containing a compound of formula (I) or pharmaceutically acceptable salt thereof which is useful as an antagonist of GnRH and may be useful for treatment of a variety of sex-hormone related and other conditions in men and women. SOLUTION: This compound is represented by formula (I) [wherein A is a 1-6C alkyl or the like; R0 is hydrogen, a 1-6C alkyl or the like; R1 is a nitrogen-containing heterocycle or the like including formula (II), formula (III), formula (IV) or formula (V); R2 is hydrogen, a 1-6C alkyl or the like; R3, R4 and R5 are each hydrogen, a 1-6C alkyl or the like; R6 is hydrogen, a 1-6C alkyl or the like; R7 is hydrogen, a 1-6C alkyl or the like; R8 is C(O)OR20, C(O)NR20R21 or the like; when (m) is not 0, R9 and R9a are each hydrogen, a 1-6C alkyl; R10 and R10a are each hydrogen, a 1-6C alkyl or the like].
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/42 | ....口恶唑 |
| ----------------A61K31/422 | .....未稠合的并含有另外的杂环的 |