发明专利
ES2375395T3 DERIVADOS DE PIRAZINA FLUORESCENTES Y METODO DE USO DE LOS MISMOS EN LA EVALUACION DE LA FUNCION RENAL.
未知
基本信息:
- 专利标题： DERIVADOS DE PIRAZINA FLUORESCENTES Y METODO DE USO DE LOS MISMOS EN LA EVALUACION DE LA FUNCION RENAL.
- 申请号：ES07013568 申请日：2005-12-22
- 公开(公告)号：ES2375395T3 公开(公告)日：2012-02-29
- 发明人： RAJAGOPALAN RAGHAVAN , NEUMANN WILLIAM L , DORSHOW RICHARD B , MOORE DENNIS A
- 申请人： MALLINCKRODT INC , MALLINCKRODT LLC MALLINCKRODT LLC
- 专利权人： MALLINCKRODT INC,MALLINCKRODT LLC MALLINCKRODT LLC
- 当前专利权人： MALLINCKRODT INC,MALLINCKRODT LLC MALLINCKRODT LLC
- 优先权： US63861104 2004-12-23
- 主分类号： C07D241/26
- IPC分类号： C07D241/26 ; A61K31/4965
The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X 1 to X 4 of Formulas I and II may be characterized as electron withdrawing groups, while Y 1 to Y 4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g. kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may be capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g. visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D241/00 | 杂环化合物，含1,4-二嗪环或氢化1,4-二嗪环 |
| --------C07D241/02 | .不与其他环稠合 |
| ----------C07D241/06 | ..环原子间或环原子与非环原子间有1个或两个双键 |
| ------------C07D241/14 | ...有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子，例如，酯基或腈基，直接连在环碳原子上 |
| --------------C07D241/20 | ....氮原子 |
| ----------------C07D241/26 | .....有氮原子直接连在环碳原子上 |