基本信息:
- 专利标题： SMALL-MOLECULE COMPOUND HAVING NAPHTHOL ETHER STRUCTURE, AND USE THEREOF
- 申请号：EP22871956.3 申请日：2022-09-20
- 公开(公告)号：EP4406937A1 公开(公告)日：2024-07-31
- 发明人： XIA, Hongguang , FAN, Mengyang , CEN, Xufeng , XU, Xiaoyan , WU, Ronghai , LIU, Dong , TIAN, Zhen
- 申请人： Hangzhou Phecdamed Co., Ltd.
- 申请人地址： CN Hangzhou, Zhejiang 311100 Room 301, Building 2 No.2626 Yuhangtang Road Yuhang District
- 专利权人： Hangzhou Phecdamed Co., Ltd.
- 当前专利权人： Hangzhou Phecdamed Co., Ltd.
- 当前专利权人地址： CN Hangzhou, Zhejiang 311100 Room 301, Building 2 No.2626 Yuhangtang Road Yuhang District
- 代理机构： Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte
- 优先权： CN 2111106864 2021.09.22
- 国际申请： CN2022119826 2022.09.20
- 国际公布： WO2023045910 2023.03.30
- 主分类号： C07C323/52
- IPC分类号： C07C323/52 ; C07C381/10 ; C07D305/08 ; C07D285/10 ; C07D285/16 ; C07D249/08 ; C07D257/04 ; C07D333/34 ; A61K31/192 ; A61K31/337 ; A61K31/381 ; A61K31/265 ; A61K31/222 ; A61K31/4196 ; A61K31/41 ; A61K31/549 ; A61K31/433 ; A61P43/00
摘要：
The present application discloses a small-molecule compound having a naphthalenethiol ether structure, and a use thereof. Disclosed in the present application are a compound having a structure represented by general formula (I), a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, a pharmaceutical composition containing the same, and a use thereof in the preparation of mitophagy inducer drugs. In the present application, the structure of the compound having the structure represented by general formula (I) is shown below. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, or the pharmaceutical composition provided in the present application can enhance the ability to induce mitophagy.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C323/00 | 被卤素、氧或氮原子或非硫代基硫原子取代的硫醇、硫醚、氢化多硫化物或多硫化物 |
| --------C07C323/23 | .硫代基和不属于硝基或亚硝基氮原子连接在同一碳架上 |
| ----------C07C323/51 | ..有硫代基的硫原子连接在碳架的非环碳原子上 |
| ------------C07C323/52 | ...碳架是无环的和饱和的 |