基本信息:
- 专利标题： MODULATING EXPRESSION OF POLYPEPTIDES VIA NEW GENE SWITCH EXPRESSION SYSTEMS
- 申请号：EP24156133.1 申请日：2018-01-10
- 公开(公告)号：EP4382913A2 公开(公告)日：2024-06-12
- 发明人： Shah, Rutul R. , Reed, Thomas D. , Bolinger, Cheryl G.
- 申请人： Precigen, Inc.
- 申请人地址： US Germantown, Maryland 20876 20358 Seneca Meadows Parkway
- 专利权人： Precigen, Inc.
- 当前专利权人： Precigen, Inc.
- 当前专利权人地址： US Germantown, Maryland 20876 20358 Seneca Meadows Parkway
- 代理机构： Pohlman, Sandra M.
- 优先权： US 1762444775P 2017.01.10
- 分案原申请号： 18702387.4 2018.01.10
- 主分类号： G01N33/68
- IPC分类号： G01N33/68
摘要：
Disclosed herein are polynucleotides encoding ligand-inducible gene switch polypeptides, and sytems comprising gene switch polypeptides for modulating the expression of a heterologous gene and an interleukin in a host cell. The compositions, methods and systems described herein facilitate ligand dependent expression of polypeptides including but not limited to cytokines and antigen binding polypeptides