基本信息:
- 专利标题： MICE EXPRESSING HUMANIZED T-CELL CO-RECEPTORS
- 申请号：EP24155637.2 申请日：2014-02-20
- 公开(公告)号：EP4374690A3 公开(公告)日：2024-08-21
- 发明人： MACDONALD, Lynn , MURPHY, Andrew, J. , TU, Naxin , VORONINA, Vera , GURER, Cagan
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： US Tarrytown, NY 10591 777 Old Saw Mill River Road
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US Tarrytown, NY 10591 777 Old Saw Mill River Road
- 代理机构： Mewburn Ellis LLP
- 优先权： US 1361766762P 2013.02.20
- 分案原申请号： 19159217.9 2019.02.25;14708430.5 2014.02.20
- 主分类号： C07K14/73
- IPC分类号： C07K14/73 ; C07K14/705 ; C12N15/85 ; A01K67/027
摘要：
The invention provides genetically modified non-human animals that express chimeric human/non-human T cell co-receptor polypeptides (e.g. CD4, CD8α, CD8β), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same.
公开/授权文献:
- EP4374690A2 MICE EXPRESSING HUMANIZED T-CELL CO-RECEPTORS 公开/授权日：2024-05-29