基本信息:
- 专利标题： SUBSTITUTED TRIAZINE COMPOUND
- 申请号：EP22795825.3 申请日：2022-04-27
- 公开(公告)号：EP4345097A1 公开(公告)日：2024-04-03
- 发明人： INAGAKI, Yusuke , YAMASHITA, Yumi , TOYA, Hiroki , WASHIO, Takuya , TAKAHASHI, Fumie , SABA, Kengo , TOMIYAMA, Hiroshi , IWAI, Yoshinori , NAKAMURA, Akihiko
- 申请人： Astellas Pharma Inc.
- 申请人地址： JP Chuo-ku Tokyo 103-8411 5-1, Nihonbashi-Honcho 2-Chome
- 代理机构： Gille Hrabal Partnerschaftsgesellschaft mbB Patentanwälte
- 优先权： JP2021075905 20210428
- 国际公布： WO2022230912 20221103
- 主分类号： C07D253/07
- IPC分类号： C07D253/07 ; A61K31/53 ; A61K31/5377 ; A61K31/55 ; A61P25/00 ; A61P29/00 ; A61P43/00 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D413/12
摘要：
An object of the present invention is to provide a pharmaceutical composition, particularly a compound suitable for preventing and/or treating an inflammatory disease and/or a neurodegenerative disease.
The present inventors accomplished the present invention by conducting intensive studies to find a compound having an inhibitory effect on NLRP3 inflammasome activation, with the result that a substituted triazine compound is found to have the inhibitory effect on NLRP3 inflammasome activation. The substituted triazine compound of the present invention is expected to serve as a preventive and/or therapeutic drug for an inflammatory disease and/or a neurodegenerative disease.
The present inventors accomplished the present invention by conducting intensive studies to find a compound having an inhibitory effect on NLRP3 inflammasome activation, with the result that a substituted triazine compound is found to have the inhibitory effect on NLRP3 inflammasome activation. The substituted triazine compound of the present invention is expected to serve as a preventive and/or therapeutic drug for an inflammatory disease and/or a neurodegenerative disease.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D253/00 | 杂环化合物，含六元环、有3个氮原子作为仅有的杂环原子，C07D251/00组不包含的 |
| --------C07D253/02 | .不和其他环稠合 |
| ----------C07D253/06 | ..1,2,4-三嗪 |
| ------------C07D253/065 | ...环原子间或环原子与非环原子间有3个双键 |
| --------------C07D253/07 | ....有杂原子，或有以3个键连杂原子、最多以1个键连卤素的碳原子，例如酯基或腈基，直接连在环碳原子上 |