发明公开
EP4242212A2 STING MODULATOR COMPOUNDS WITH SULFAMATE LINKAGES, AND METHODS OF MAKING AND USING
审中-实审
基本信息:
- 专利标题： STING MODULATOR COMPOUNDS WITH SULFAMATE LINKAGES, AND METHODS OF MAKING AND USING
- 申请号：EP23162945.2 申请日：2019-03-22
- 公开(公告)号：EP4242212A2 公开(公告)日：2023-09-13
- 发明人： CIAVARRi, Jeffrey , ENGLAND, Dylan Bradley , GIGSTAD, Kenneth M. , GOULD, Alexandra E. , GREENSPAN, Paul , HU, Yongbo , HUANG, Shih-Chung , LANGSTON, Steven Paul , MIZUTANI, Hirotake , SHI, Zhan , VYSKOCIL, Stepan , XU, He
- 申请人： Takeda Pharmaceutical Company Limited
- 申请人地址： JP Osaka-shi, Osaka 541-0045 1-1, Doshomachi 4-chome Chuo-ku
- 代理机构： Harris, Jennifer Lucy
- 优先权： US201962821831 P 20190321
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; C07F9/09 ; A61P35/00 ; A61K31/675
摘要：
The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I):
wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D519/00 | 杂环化合物，含有1个以上的由两个或更多个相关杂环组成的环系，杂环间彼此稠合，或与1个共同碳环系稠合，不包含在C07D453/00或C07D455/00组内 |