发明公开
EP3868409A1 CONNECTOR FOR USE IN ANTIBODY MEDICAMENT CONJUGATE AND APPLICATIONS OF CONNECTOR
有权
基本信息:
- 专利标题： CONNECTOR FOR USE IN ANTIBODY MEDICAMENT CONJUGATE AND APPLICATIONS OF CONNECTOR
- 申请号：EP19900942.4 申请日：2019-12-13
- 公开(公告)号：EP3868409A1 公开(公告)日：2021-08-25
- 发明人： HUANG, Changjiang , YE, Hui , CHEN, Hu , ZHAN, Xiuzhi , SHEN, Nan , LUO, Wenting , HOU, Qiaohua , FANG, Jianmin
- 申请人： RemeGen Co., Ltd.
- 申请人地址： CN Shandong 264006 China (Shandong) Pilot Free Trade Zone Yantai District, Yantai Development Zone No.58 Beijing Middle Road
- 代理机构： Bottero, Carlo
- 优先权： CN201811541356 20181217
- 国际公布： WO2020125546 20200625
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; A61K39/395 ; C07D207/448 ; C07D207/452 ; A61P35/00
摘要：
The present invention provides a linker for preparing antibody-drug conjugates and antibody-drug conjugates prepared by the linker, as well as use of the antibody-drug conjugates in a medicament for treating tumor. The linker is capable of coupling simultaneously with the thiol group or amino group on the antibody or functional fragment of the antibody, especially it is capable of coupling with 2, 3 or 4 thiol groups on the antibody or functional fragment of the antibody. A coupled product is uniform and structurally stable.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/50 | .非有效成分被化学键合到有效成分上，例如聚合物－药物结合物 |
| ----------A61K47/66 | ..该改性剂是靶向特定细胞的涉及肽或蛋白质的预靶向系统 |
| ------------A61K47/68 | ...该改性剂是抗体、免疫球蛋白或其片段，例如Fc-片段 |