基本信息:
- 专利标题： METHOD FOR IDENTIFYING NOVEL MINOR HISTOCOMPATIBILITY ANTIGENS
- 申请号：EP19212576.3 申请日：2013-07-25
- 公开(公告)号：EP3639831A1 公开(公告)日：2020-04-22
- 发明人： PERREAULT, Claude , THIBAULT, Pierre , LEMIEUX, Sébastien , GRANADOS, Diana Paola , DEV, Sriranganadane , DAOUDA, Mohamed Tariq , CARON-LIZOTTE, Olivier
- 申请人： Université de Montréal
- 申请人地址： 2900 Rue Edouard-Montpetit Montréal, QC H3T 1J4 CA
- 专利权人： Université de Montréal
- 当前专利权人： Université de Montréal
- 当前专利权人地址： 2900 Rue Edouard-Montpetit Montréal, QC H3T 1J4 CA
- 代理机构： Brevalex
- 优先权： US201261683361P 20120815; US201361818040P 20130501
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61P35/00 ; C07K7/06 ; C12N15/12 ; C12Q1/6886 ; G01N33/569 ; G16B20/00 ; G16B30/00
摘要：
A novel method for human minor histocompatibility antigen (MiHA) discovery, novel MiHAs identified using this method, as well as uses of the novel MiHAs, are described. One of the features of the novel method is the inclusion of personalized translated transcriptome and/or exome in the database used for peptide identification by mass spectroscopy (MS). Candidate MiHAs are identified by comparing the personalized transcriptome and/or exome to a reference genome and/or to the transcriptome and/or exome of an HLA-matched subject.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |
| --------A61K35/02 | .来源于非生命物质的 |
| ----------A61K35/14 | ..血液 |
| ------------A61K35/17 | ...淋巴细胞；B细胞；T细胞；自然杀伤细胞；干扰素激活或细胞因子激活的淋巴细胞 |