发明公开
EP3578174A1 USE OF (+)-2-BORNEOL IN PREPARATION OF DRUG FOR PROMOTING UPREGULATION OF EXPRESSION OF SPHINGOSINE KINASE-1 AND/OR BDNF
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基本信息:
- 专利标题： USE OF (+)-2-BORNEOL IN PREPARATION OF DRUG FOR PROMOTING UPREGULATION OF EXPRESSION OF SPHINGOSINE KINASE-1 AND/OR BDNF
- 申请号：EP17916830.7 申请日：2017-07-07
- 公开(公告)号：EP3578174A1 公开(公告)日：2019-12-11
- 发明人： LI, Yunsen , DENG, Shiping , LI, Yong , JIANG, Chuanliang , YU, Yunhui
- 申请人： Suzhou Pharmavan Cancer Research Center Co., Ltd.
- 申请人地址： Floor 5, Building No. 7 DongFang Industrial District C No. 1 Huayun Road Suzhou Industrial Park Suzhou, Jiangsu 215000 CN
- 专利权人： Suzhou Pharmavan Cancer Research Center Co., Ltd.
- 当前专利权人： Suzhou Pharmavan Cancer Research Center Co., Ltd.
- 当前专利权人地址： Floor 5, Building No. 7 DongFang Industrial District C No. 1 Huayun Road Suzhou Industrial Park Suzhou, Jiangsu 215000 CN
- 代理机构： Plougmann Vingtoft a/s
- 国际公布： WO2019006734 20190110
- 主分类号： A61K31/045
- IPC分类号： A61K31/045 ; A61P25/28
摘要：
Disclosed is the use of (+)-2-borneol in the preparation of a drug for promoting the upregulation of the expression of sphingosine kinase-1 and/or BDNF (a brain-derived neurotrophic factor). Herein, (+)-2-borneol can be used to prepare a drug for promoting the upregulation of the expression of the sphingosine kinase-1 and/or the brain-derived neurotrophic factor. The drug can induce astrocyte spreading and migration, oligodendrocyte differentiation and survival, and neurite growth and nerve regeneration, and can promote the upregulation of the expression of the brain-derived neurotrophic factor, promote the survival of neurons and the growth of axons, inhibit the expansion of the infarct volume, and achieve the effect of repairing damage at the site of an immediate injury while preventing further expansion of the infarct area to completely treat brain damage, so that the long-term therapeutic effect thereof is significantly improved.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |