发明公开
EP3551622A1 MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
有权
基本信息:
- 专利标题： MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
- 申请号：EP17826629.2 申请日：2017-12-08
- 公开(公告)号：EP3551622A1 公开(公告)日：2019-10-16
- 发明人： ABELA, Alexander, Russell , ALCACIO, Timothy , ANDERSON, Corey , ANGELL, Paul, Timothy , BAEK, Minson , CLEMENS, Jeremy, J. , CLEVELAND, Thomas , FERRIS, Lori, Ann , GROOTENHUIS, Peter Diederik, Jan , GROSS, Raymond, Stanley , GULEVICH, Anton , HADIDA RUAH, Sara, Sabina , HSIA, Clara, Kuang-Ju , HUGHES, Robert, M. , JOSHI, Pramod, Virupax , KANG, Ping , KESHAVARZ-SHOKRI, Ali , KHATUYA, Haripada , KRENITSKY, Paul, John , MCCARTNEY, Jason , MILLER, Mark, Thomas , PARASELLI, Prasuna , PIERRE, Fabrice Jean, Denis , SHI, Yi , SHRESTHA, Muna , SIESEL, David, Andrew , STAVROPOULOS, Kathy , TERMIN, Andreas, P. , UY, Johnny , VAN GOOR, Fredrick, F. , YOUNG, Tomothy, John , ZHOU, Jinglan
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： 50 Northern Avenue Boston, MA 02210 US
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： 50 Northern Avenue Boston, MA 02210 US
- 代理机构： Oates, Edward Christopher
- 优先权： US201662432537P 20161209
- 国际公布： WO2018107100 20180614
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D401/04 ; C07D231/20 ; A61K31/455 ; A61P11/00
摘要：
pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/14 | .含有3个或更多个杂环 |