发明公开
EP3492455A1 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USE IN THE TREATMENT OF SPECIFIC FORMS OF CANCER
有权
基本信息:
- 专利标题： 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USE IN THE TREATMENT OF SPECIFIC FORMS OF CANCER
- 申请号：EP18202641.9 申请日：2014-06-20
- 公开(公告)号：EP3492455A1 公开(公告)日：2019-06-05
- 发明人： BALOGLU, Erkan , SHACHAM, Sharon , MCCAULEY, Dilara , KASHYAP, Trinayan , SENAPEDIS, William , LANDESMAN, Yosef , GOLAN, Gali , KALID, Ori , SHECHTER, Sharon
- 申请人： Karyopharm Therapeutics Inc.
- 申请人地址： 85 Wells Avenue Newton, MA 02459 US
- 专利权人： Karyopharm Therapeutics Inc.
- 当前专利权人： Karyopharm Therapeutics Inc.
- 当前专利权人地址： 85 Wells Avenue Newton, MA 02459 US
- 代理机构： Snodin, Michael D.
- 优先权： US201361838172P 20130621
- 主分类号： C07D249/08
- IPC分类号： C07D249/08 ; A61K31/497 ; A61P35/00 ; C07D401/06 ; C07D403/06 ; C07D405/06 ; C07D413/06 ; C07D417/06
摘要：
The present invention relates to compounds of formula I:
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D249/00 | 杂环化合物，含五元环，有3个氮原子作为仅有的杂环原子 |
| --------C07D249/02 | .不与其他环稠合 |
| ----------C07D249/08 | ..1,2,4-三唑；氢化1,2,4-三唑 |