发明公开
EP3450423A1 BENZYL PHENYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
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基本信息:
- 专利标题： BENZYL PHENYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
- 申请号：EP17802119.2 申请日：2017-05-23
- 公开(公告)号：EP3450423A1 公开(公告)日：2019-03-06
- 发明人： FENG, Zhiqiang , CHEN, Xiaoguang , YANG, Yang , LAI, Fangfang , JI, Ming , ZHANG, Lijing , ZHENG, Yi , XUE, Nina , WANG, Ke , LI, Ling
- 申请人： Institute of Materia Medica, Chinese Academy of Medical Sciences
- 申请人地址： No. 1, Xian Nong Tan Street Xuanwu District Beijing 100050 CN
- 专利权人： Institute of Materia Medica, Chinese Academy of Medical Sciences
- 当前专利权人： INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF ME
- 当前专利权人地址： INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF ME
- 代理机构： Stephens, Clare Jean
- 优先权： CN201610343960 20160523
- 国际公布： WO2017202273 20171130
- 主分类号： C07C255/54
- IPC分类号： C07C255/54 ; C07C233/36 ; C07C311/05 ; C07D319/18 ; C07D405/12 ; A61K31/277 ; A61K31/36 ; A61K31/165 ; A61P35/00 ; A61P31/00 ; A61P37/00
摘要：
The present invention discloses a benzyl phenyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to benzyl phenyl ether derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C255/00 | 羧酸腈 |
| --------C07C255/01 | .含有连接非环碳原子的氰基 |
| ----------C07C255/54 | ..含有连接碳架的氰基和醚化的羟基 |