发明公开
EP3408299A1 ANTI-VWF D'D3 SINGLE-DOMAIN ANTIBODIES AND POLYPEPTIDES COMPRISING THEREOF
审中-实审
转让
基本信息:
- 专利标题： ANTI-VWF D'D3 SINGLE-DOMAIN ANTIBODIES AND POLYPEPTIDES COMPRISING THEREOF
- 申请号：EP17702059.1 申请日：2017-01-25
- 公开(公告)号：EP3408299A1 公开(公告)日：2018-12-05
- 发明人： LENTING, Petrus , AYME, Gabriel , DENIS, Cécile , CHRISTOPHE, Olivier
- 申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Universite Paris-Sud
- 申请人地址： 101, rue de Tolbiac 75013 Paris FR
- 专利权人： INSERM - Institut National de la Santé et de la Recherche Médicale,Universite Paris-Sud
- 当前专利权人： UNIVERSITE PARIS-SACLAY
- 当前专利权人地址： UNIVERSITE PARIS-SACLAY
- 代理机构： Inserm Transfert
- 优先权： EP16305071 20160126
- 国际公布： WO2017129630 20170803
- 主分类号： C07K16/36
- IPC分类号： C07K16/36 ; C07K14/755 ; C07K14/745 ; A61P7/04
摘要：
The invention relates to isolated single-domain antibodies (sdAb) directed against von Willebrand Factor (VWF) D'D3 domain and chimeric polypeptides comprising thereof such as blood clotting factors and their uses in therapy such as in the prevention and treatment of hemostatic disorders. The invention also relates to a method of extending or increasing half-life of a therapeutic polypeptide comprising a step of adding to the polypeptide sequence of said therapeutic polypeptide at least one sdAb directed against VWF D'D3 domain.