发明公开
EP3384074A1 PUCE MICROFLUIDIQUE POUR LA CRISTALLISATION DE MOLECULES, PROCEDE DE PREPARATION, DISPOSITIF LA COMPRENANT ET PROCEDE DE CRISTALLISATION DE MOLECULES
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基本信息:
- 专利标题： PUCE MICROFLUIDIQUE POUR LA CRISTALLISATION DE MOLECULES, PROCEDE DE PREPARATION, DISPOSITIF LA COMPRENANT ET PROCEDE DE CRISTALLISATION DE MOLECULES
- 专利标题（英）：EP3384074A1 - Microfluidic chip for molecule crystallisation, preparation method, device comprising same and molecule crystallisation method
- 申请号：EP16819151.8 申请日：2016-12-02
- 公开(公告)号：EP3384074A1 公开(公告)日：2018-10-10
- 发明人： SPANO, Monika , SALMON, Jean-Baptiste , JUNIUS, Niels Heinz
- 申请人： Université Grenoble Alpes
- 申请人地址： 621 avenue Centrale 38400 Saint-Martin-d'Hères FR
- 专利权人： Université Grenoble Alpes
- 当前专利权人： UNIVERSITE DE BORDEAUX; FR
- 当前专利权人地址： UNIVERSITE DE BORDEAUX; FR
- 代理机构： Hautier, Nicolas
- 优先权： FR1561715 20151202
- 国际公布： WO2017093689 20170608
- 主分类号： C30B29/58
- IPC分类号： C30B29/58 ; B01L3/00 ; C30B7/08 ; C30B7/14
摘要：
The present invention relates to a microfluidic chip (1) comprising at least one dialysis crystallisation cell (11), said cell (11) comprising: a substrate (1111) made of PMMA, a first stage comprising a vessel (111) defined at least partially by said substrate (1111) and by an outer wall (1112) of the cell, said vessel (111) being in fluid communication with an inlet channel and an outlet channel for a solution allowing the crystallisation method to be carried out, a second stage comprising a dialysis chamber (113) defined at least partially by an inner wall (1113) of the cell not in contact with the substrate (1111) and by a dialysis membrane (112) forming an interface between the vessel (111) and the dialysis chamber (113), the inner wall (1113) comprising at least one integral portion in which the periphery of said membrane (112) is kept sealed. The present invention likewise relates to a method for preparing such a chip and crystallisation methods carried out using such a chip.