基本信息:
- 专利标题： AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
- 申请号：EP16840986.0 申请日：2016-09-02
- 公开(公告)号：EP3344640A1 公开(公告)日：2018-07-11
- 发明人： BAASOV, Timor
- 申请人： Eloxx Pharmaceuticals Ltd.
- 申请人地址： 10 Prof. Menachem Plaut Street 7670621 Rehovot IL
- 专利权人： Eloxx Pharmaceuticals Ltd.
- 当前专利权人： Eloxx Pharmaceuticals Ltd.
- 当前专利权人地址： 10 Prof. Menachem Plaut Street 7670621 Rehovot IL
- 代理机构： Van Breda, Jacobus
- 优先权： US201562213143P 20150902
- 国际公布： WO2017037717 20170309
- 主分类号： C07H15/23
- IPC分类号： C07H15/23 ; A61K31/7036 ; A61P7/04 ; A61P21/04 ; C07H15/222 ; C07H15/224
摘要：
Novel pseudo-disaccharide and pseudo-trisaccharide aminoglycosides, represented by Formulae I or Ia, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07H | 糖类；及其衍生物；核苷；核苷酸；核酸 |
| ------C07H15/00 | 含有直接连在糖化物基团的杂原子上的烃基或取代烃基的化合物 |
| --------C07H15/20 | .碳环类 |
| ----------C07H15/22 | ..被氮原子取代的环己烷环 |
| ------------C07H15/222 | ...至少被两个氮原子取代的环己烷环 |
| --------------C07H15/226 | ....至少有两个糖化物基团直接连在环己烷环上 |
| ----------------C07H15/228 | .....连在环己烷环的相邻环碳原子上 |
| ------------------C07H15/23 | ......分子中只有两上糖化物基团，例如丁酰甘霉素、丁酸素木糖霉素、核糖霉素 |