基本信息:
- 专利标题： SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS
- 申请号：EP16818524.7 申请日：2016-06-27
- 公开(公告)号：EP3328840A1 公开(公告)日：2018-06-06
- 发明人： MORRIELLO, Gregori, J. , CHANG, Lehua , FORSTER, Ashley , CHEN, Yili , DWYER, Michael, P. , GUO, Zack Zhiqiang , WANG, Ming , XU, Shimin , BO, Yingjian , FU, Jianmin
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Jaap, David Robert
- 优先权： PCT/CN2015/083060 20150701
- 国际公布： WO2017003894 20170105
- 主分类号： C07D249/00
- IPC分类号： C07D249/00 ; A61K31/519 ; A61K31/52 ; C07D235/00 ; C07D487/04
摘要：
The present invention is directed to substituted triazolo bicyclic compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D249/00 | 杂环化合物，含五元环，有3个氮原子作为仅有的杂环原子 |