基本信息:
- 专利标题： METALLO-BETA-LACTAMASE INHIBITORS
- 专利标题（中）：金属-β-内酰胺酶抑制剂
- 申请号：EP16815358.3 申请日：2016-06-24
- 公开(公告)号：EP3313828A1 公开(公告)日：2018-05-02
- 发明人： BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack, D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , HUNTER, David , YANG, Dexi , YOUNG, Katherine , XIAO, Li , ZHANG, Zhibo , FU, Jianmin , BAI, Yunfeng , ZHENG, Zhixiang , ZHANG, Xu
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： MERCK SHARP & DOHME LLC
- 当前专利权人地址： MERCK SHARP & DOHME LLC
- 代理机构： Böhles, Elena
- 优先权： PCT/CN2015/082514 20150626
- 国际公布： WO2016210234 20161229
- 主分类号： C07D257/02
- IPC分类号： C07D257/02 ; C07D257/04 ; A61K31/41 ; A61K31/395
摘要：
The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X 2 and R1are as defined herein. The present invention also relates to compositions which comprise a metallo-beta-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
公开/授权文献:
- EP3313828B1 METALLO-BETA-LACTAMASE INHIBITORS 公开/授权日：2023-07-12
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D257/00 | 杂环化合物，有4个氮原子作为仅有的杂环原子的环 |
| --------C07D257/02 | .不与其他环稠合 |