![NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-D]PYRIMIDINES AS LRRK2 INHIBITORS](/ep/2017/12/13/EP3255049A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题： NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-D]PYRIMIDINES AS LRRK2 INHIBITORS
- 申请号：EP17175308.0 申请日：2013-06-19
- 公开(公告)号：EP3255049A1 公开(公告)日：2017-12-13
- 发明人： GALATSIS, Paul , HAYWARD, Matthew Merrill , HENDERSON, Jaclyn , KORMOS, Bethany Lyn , KURUMBAIL, Ravi G. , STEPAN, Antonia Friederike , VERHOEST, Patrick Robert , WAGER, Travis T. , ZHANG, Lei
- 申请人： Pfizer Inc.
- 申请人地址： 235 East 42nd Street New York, NY 10017 US
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： 235 East 42nd Street New York, NY 10017 US
- 代理机构： Pfizer
- 优先权： US201261666299P 20120629; US201361820828P 20130508
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D519/00
摘要：
The present invention provides novel 4,5-disubstituted-7 H -pyrrolo[2,3- d ]pyrimidine derivatives of Formula I, and the pharmaceutically acceptable salts thereof
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物，不包含在C07D451/00至C07D477/00组中 |
| --------C07D487/02 | .在稠合系中含有两个杂环 |
| ----------C07D487/04 | ..邻位稠合系 |