EP3235817B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS
有权
基本信息:
- 专利标题： LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS
- 申请号：EP17169751.9 申请日：2014-03-14
- 公开(公告)号：EP3235817B1 公开(公告)日：2018-12-12
- 发明人： BARRETT, Stephen, Douglas , COLOMBO, Joseph, Michael , GERMAIN, Bradlee, David , ENDRES, Gregory, William , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , CISKE, Fred, Lawrence , MAXEY, Kirk, M. , O'MALLEY, James, Paul , OWEN, Thomas, Allen
- 申请人： Cayman Chemical Company, Incorporated
- 申请人地址： 1180 E. Ellsworth Road Ann Arbor, Michigan 48108 US
- 专利权人： Cayman Chemical Company, Incorporated
- 当前专利权人： Cayman Chemical Company, Incorporated
- 当前专利权人地址： 1180 E. Ellsworth Road Ann Arbor, Michigan 48108 US
- 代理机构： D Young & Co LLP
- 优先权： US201361793736P 20130315
- 主分类号： C07D417/06
- IPC分类号： C07D417/06 ; C07D207/26 ; A61K31/427 ; A61P27/06
摘要：
Disclosed herein are compounds of formula (I) wherein L 1 , L 2 , L 3 , L 4 , R 1 , R 4 , R 5 , R 6 , and s are as defined in the specification. Compounds of formula (I) are EP 4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D417/00 | 杂环化合物，含两个或更多个杂环、至少有1个环有氮原子和硫原子作为仅有的杂环原子，C07D415/00组不包含的 |
| --------C07D417/02 | .含有两个杂环 |
| ----------C07D417/06 | ..被仅含脂族碳原子的碳链连接的 |