基本信息:
- 专利标题： SURVIVIN SPECIFIC T-CELL RECEPTOR TARGETING TUMOR BUT NOT T CELLS
- 申请号：EP15854854 申请日：2015-10-30
- 公开(公告)号：EP3212774A4 公开(公告)日：2018-04-11
- 发明人： SAVOLDO BARBARA , DOTTI GIANPIETRO , ARBER BARTH CAROLINE EVA
- 申请人： BAYLOR COLLEGE MEDICINE
- 专利权人： BAYLOR COLLEGE MEDICINE
- 当前专利权人： BAYLOR COLLEGE MEDICINE
- 优先权： US201462073076 2014-10-31
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C12N5/0783 ; C12N5/09
摘要：
Embodiments of the disclosure concern engineered T cell receptors that are specific for the survivin tumor antigen but do not have “on-target off tumor” toxicity. In particular embodiments, particular alpha and beta chains are utilized in engineered T cell receptors for cell therapy that have effective anti-tumor activity but lack fratricidal effects. Methods, compositions, and kits are provided herein.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/415 | .来自植物 |
| ----------C07K14/44 | ..来自原生动物门 |
| ------------C07K14/725 | ...T-细胞受体 |