基本信息:
- 专利标题： METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE RESPONSES
- 专利标题（中）：提高免疫应答的方法和组合物
- 申请号：EP15771771.1 申请日：2015-09-03
- 公开(公告)号：EP3188754A1 公开(公告)日：2017-07-12
- 发明人： VOLKMANN, Ariane , STEIGERWALD, Robin , DIRMEIER, Ulrike , CALLENDRET, Benoit Christophe Stephan , DOUOGUIH, Macaya Julie , WARD, Lucy A.
- 申请人： Bavarian Nordic A/S , Janssen Vaccines & Prevention B.V. , The United States of America, as represented by The Secretary, Department of Health and Human Services
- 申请人地址： Hejreskovvej 10A 3490 Kvistgaard DK
- 专利权人： Bavarian Nordic A/S,Janssen Vaccines & Prevention B.V.,The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人： Bavarian Nordic A/S,Janssen Vaccines & Prevention B.V.,The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人地址： Hejreskovvej 10A 3490 Kvistgaard DK
- 代理机构： Høiberg P/S
- 优先权： US201462045522P 20140903; US201562116021P 20150213; US201562159823P 20150511; US201562189109P 20150706
- 国际公布： WO2016036971 20160310
- 主分类号： A61K39/12
- IPC分类号： A61K39/12
摘要：
Compositions and methods are described for generating an improved effective immune response against an immunogen in humans. The enhanced immune response, is obtained by using an MVA vector as a prime and an adenovirus vector as a boost and is characterized by a high level of antibody response specific to the immunogen, and an enhanced cellular immune response. The compositions and methods can be used to provide a protective immunity against a disease, such as an infection of one or more subtypes of Ebola and Marburg filoviruses, in humans.
摘要（中）：
描述了组合物和方法用于产生抗人免疫原的改善的有效免疫应答。 通过使用MVA载体作为主要载体和腺病毒载体作为加强剂获得增强的免疫应答，其特征在于对免疫原特异性的高水平抗体应答和增强的细胞免疫应答。 该组合物和方法可用于提供针对人的疾病的保护性免疫，例如埃博拉病毒和马尔堡病毒的一种或多种亚型的感染。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/12 | .病毒性抗原 |