发明公开
EP3113794A2 METHODS AND COMPOSITIONS FOR INCREASING A T-EFFECTOR CELL TO REGULATORY T CELL RATIO
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基本信息:
- 专利标题： METHODS AND COMPOSITIONS FOR INCREASING A T-EFFECTOR CELL TO REGULATORY T CELL RATIO
- 专利标题（中）：方法和组合物之间的T效应细胞和调节性T细胞的关系增加
- 申请号：EP15758226.3 申请日：2015-03-05
- 公开(公告)号：EP3113794A2 公开(公告)日：2017-01-11
- 发明人： PETIT, Robert , WALLECHA, Anu , CHEN, Zhisong , BERZOFSKY, Jay A. , KHLEIF, Samir
- 申请人： Advaxis, Inc. , National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government
- 申请人地址： 305 College Road East Princeton, NJ 08540 US
- 专利权人： Advaxis, Inc.,National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government
- 当前专利权人： Advaxis, Inc.,National Institutes of Health, as represented by the Secretary, Department of Health and Human Services of the Government
- 当前专利权人地址： 305 College Road East Princeton, NJ 08540 US
- 代理机构： Bentham, Andrew
- 优先权： US201461948453P 20140305
- 国际公布： WO2015134722 20150911
- 主分类号： A61K39/02
- IPC分类号： A61K39/02
摘要：
The present invention is directed to methods for increasing T-cell effector cell to regulatory T cell ratio. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor, comprising the step of administering to a subject a recombinant
Listeria strain, comprising a fusion peptide that comprises an LLO fragment and tumor-associated antigen.
摘要（中）：
Listeria strain, comprising a fusion peptide that comprises an LLO fragment and tumor-associated antigen.
本发明涉及用于提高T细胞的效应细胞，以调节性T细胞的比率的方法。 本发明还涉及治疗，保护免受，和针对肿瘤的免疫应答的诱导，包括给予受试者的重组李斯特菌菌株，其包含融合肽确实LLO片段和肿瘤相关抗原的步骤包括的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/02 | .细菌性抗原 |