EP3056899B1 GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
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基本信息:
- 专利标题： GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF
- 专利标题（中）：遗传多态性与静脉桥反应和心血管疾病相关，检测方法及其应用
- 申请号：EP16153844.2 申请日：2011-04-15
- 公开(公告)号：EP3056899B1 公开(公告)日：2018-03-28
- 发明人： SHIFFMAN, Dov , DEVLIN, James J. , LUKE, May , ROSS, David
- 申请人： Celera Corporation
- 申请人地址： 1311 Calle Batido, Suite 175 San Clemente, CA 92673 US
- 专利权人： Celera Corporation
- 当前专利权人： CELERA CORPORATION, SAN JUAN CAPISTRANO, US
- 当前专利权人地址： CELERA CORPORATION, SAN JUAN CAPISTRANO, US
- 代理机构： Jones Day
- 优先权： US325689P 20100419; US332509P 20100507; US405972P 20101022
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; G06F19/18
摘要：
The invention provides a method for predicting statin responsiveness in a human, the method comprising testing a sample of nucleic acid from said human for the presence or absence of a single nucleotide polymorphism (SNP) in the nucleotide sequence of SEQ ID NO:903 (rs3732788), wherein said human is determined to have an increased statin responsiveness due to the presence of C at position 101 of SEQ ID NO:903 or the presence of G at position 101 of its complement. Further provided are uses of a detection reagent and a kit for predicting said statin responsiveness.