EP3022179B1 PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)
有权
基本信息:
- 专利标题： PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)
- 专利标题（中）：苯基氨基甲酸酯及其作为D3多巴明受体（D3DR）的脂肪酸酰胺水解酶（FAAH）酶和调节剂的抑制剂的用途
- 申请号：EP14744009.3 申请日：2014-07-10
- 公开(公告)号：EP3022179B1 公开(公告)日：2017-11-15
- 发明人： BOTTEGONI, Giovanni , DE SIMONE, Alessio , RUDA, Gian Filippo , CAVALLI, Andrea , BANDIERA, Tiziano , PIOMELLI, Daniele
- 申请人： Fondazione Istituto Italiano Di Tecnologia , The Regents of the University of California
- 申请人地址： Via Morego 30 16163 Genova IT
- 专利权人： Fondazione Istituto Italiano Di Tecnologia,The Regents of the University of California
- 当前专利权人： Fondazione Istituto Italiano Di Tecnologia,The Regents of the University of California
- 当前专利权人地址： Via Morego 30 16163 Genova IT
- 代理机构： Bianchetti Bracco Minoja S.r.l.
- 优先权： US201361847807P 20130718
- 国际公布： WO2015007615 20150122
- 主分类号： C07D209/88
- IPC分类号： C07D209/88 ; C07D211/38 ; C07D213/30 ; C07D295/125 ; C07D295/13 ; A61K31/495 ; A61K31/496 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/30 ; C07D211/14
摘要：
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar′, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D209/00 | 杂环化合物，含五元环、与其他环稠合、带1个氮原子作为惟一的杂环原子 |
| --------C07D209/02 | .与一个碳环稠合 |
| ----------C07D209/58 | ..［b］-或［c］-稠合 |
| ------------C07D209/82 | ...咔唑；氢化咔唑 |
| --------------C07D209/88 | ....有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子，例如，酯基或腈基，直接连在环系的碳原子上 |