基本信息:
- 专利标题： TETHERING CYSTEINE RESIDUES USING CYCLIC DISULFIDES
- 专利标题（中）：半胱氨酸残基的圈养通过循环DISULFIDE
- 申请号：EP13854478 申请日：2013-11-15
- 公开(公告)号：EP2920196A4 公开(公告)日：2016-06-01
- 发明人： AGAR JEFFREY N , SALISBURY JOSEPH
- 申请人： UNIV BRANDEIS
- 专利权人： UNIV BRANDEIS
- 当前专利权人： UNIV BRANDEIS
- 优先权： US201261726776 2012-11-15
- 主分类号： C07K1/10
- IPC分类号： C07K1/10
摘要：
Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.