发明公开
EP2872151A1 ACELLULAR PRO-TOLEROGENIC COMPOSITIONS FOR THE TREATMENT/PREVENTION OF AUTO-IMMUNE DISEASES
有权
基本信息:
- 专利标题： ACELLULAR PRO-TOLEROGENIC COMPOSITIONS FOR THE TREATMENT/PREVENTION OF AUTO-IMMUNE DISEASES
- 专利标题（中）：对于自身免疫性疾病的治疗/预防脱细胞PRO-致耐受性的组合物
- 申请号：EP13817292.9 申请日：2013-07-12
- 公开(公告)号：EP2872151A1 公开(公告)日：2015-05-20
- 发明人： SCOTT, Mark D. , WANG, Duncheng , TOYOFUKU, Wendy M.
- 申请人： Canadian Blood Services
- 申请人地址： Research & Development 1800 Alta Vista Drive Ottawa, Ontario K1G 4J5 CA
- 专利权人： Canadian Blood Services
- 当前专利权人： Canadian Blood Services
- 当前专利权人地址： Research & Development 1800 Alta Vista Drive Ottawa, Ontario K1G 4J5 CA
- 代理机构： Cabinet Plasseraud
- 优先权： CA2782942 20120712; US201261670694P 20120712; US201261670636P 20120712
- 国际公布： WO2014008609 20140116
- 主分类号： A61K35/14
- IPC分类号： A61K35/14 ; A61K31/7105 ; A61K47/30 ; A61P37/02 ; C12N5/078 ; C12N5/0783
摘要：
This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, two allogeneic leukocyte populations are contacted (in vivo, in vitro or ex vivo) and one of these leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition. Cellular-based preparations and processes for achieving cellular therapy are also provided.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |
| --------A61K35/02 | .来源于非生命物质的 |
| ----------A61K35/14 | ..血液 |