发明公开
EP2872149A1 METHOD FOR INDUCING IMMUNE TOLERANCE USING NON-PROLIFERATIVE POLYMER-MODIFIED ALLOGENEIC LEUKOCYTES
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基本信息:
- 专利标题： METHOD FOR INDUCING IMMUNE TOLERANCE USING NON-PROLIFERATIVE POLYMER-MODIFIED ALLOGENEIC LEUKOCYTES
- 专利标题（中）：程序，旨在确保免疫耐受使用非增殖性聚合物改性异体血液白细胞
- 申请号：EP13816754.9 申请日：2013-07-12
- 公开(公告)号：EP2872149A1 公开(公告)日：2015-05-20
- 发明人： SCOTT, Mark D. , WANG, Duncheng , TOYOFUKU, Wendy M.
- 申请人： Canadian Blood Services
- 申请人地址： Research & Development 1800 Alta Vista Drive Ottawa, Ontario K1G 4J5 CA
- 专利权人： Canadian Blood Services
- 当前专利权人： Canadian Blood Services
- 当前专利权人地址： Research & Development 1800 Alta Vista Drive Ottawa, Ontario K1G 4J5 CA
- 代理机构： Cabinet Plasseraud
- 优先权： US201261670636P 20120712; US201261670694P 20120712; CA2782942 20120712
- 国际公布： WO2014008612 20140116
- 主分类号： A61K35/14
- IPC分类号： A61K35/14 ; A61K47/30 ; A61P35/02 ; C12N5/078
摘要：
This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population. The non-proliferative allogeneic leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition with the latter leukocyte population. Cellular-based preparations and processes for achieving cellular therapy are also provided.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |
| --------A61K35/02 | .来源于非生命物质的 |
| ----------A61K35/14 | ..血液 |