发明公开
EP2861255A2 DIAGNOSTIC AND TREATMENT METHODS IN SUBJECTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY
有权
转让
基本信息:
- 专利标题： DIAGNOSTIC AND TREATMENT METHODS IN SUBJECTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY
- 专利标题（中）：诊断和治疗方法对癌症治疗耐药病人及抗日战争癌症治疗的风险
- 申请号：EP13734243.2 申请日：2013-06-19
- 公开(公告)号：EP2861255A2 公开(公告)日：2015-04-22
- 发明人： BERNSTEIN, Bradley, E. , ASTER, Jon, C. , BRADNER, James, E. , KNOECHEL, Birgit , OTT, Christopher, J. , ROOT, David
- 申请人： The Broad Institute, Inc. , The Brigham and Women's Hospital, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation d/b/a Massachusetts General Hospital
- 申请人地址： 415 Main Street, Room 7003 Cambridge, MA 02142 US
- 专利权人： The Broad Institute, Inc.,The Brigham and Women's Hospital, Inc.,Dana-Farber Cancer Institute, Inc.,The General Hospital Corporation d/b/a Massachusetts General Hospital
- 当前专利权人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人地址： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 代理机构： Bounaga, Sakina
- 优先权： US201261661772P 20120619; US201261661884P 20120620; US201361780665P 20130313
- 国际公布： WO2013192274 20131227
- 主分类号： A61K45/06
- IPC分类号： A61K45/06 ; A61K31/5517 ; A61P35/00 ; A61P35/02
摘要：
The invention relates to methods of treatment and diagnosis of subjects with cancer. In some aspects, the invention relates to methods of treatment and diagnosis of subjects with cancer, wherein the cancer is characterized by a Notch pathway activation mutation or by resistance to a Notch pathway inhibitor.
摘要（中）：
本发明涉及治疗和患有癌症的受试者的诊断的方法。 在一些方面，本发明涉及治疗和患有癌症的受试者的诊断方法中，所述癌症worin由Notch途径激活突变或通过向Notch途径抑制剂的抗性特征的。
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K45/00 | 在A61K31/00至A61K41/00各组中不包含的含有效成分的医用配制品 |
| --------A61K45/06 | .无化学特性之有效成分的混合物，例如消炎药和强心剂 |