发明公开
EP2839281A1 COMPOSITIONS AND METHODS FOR IDENTIFYING AND DIAGNOSING SALT SENSITIVITY OF BLOOD PRESSURE
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基本信息:
- 专利标题： COMPOSITIONS AND METHODS FOR IDENTIFYING AND DIAGNOSING SALT SENSITIVITY OF BLOOD PRESSURE
- 专利标题（中）：组合物和方法识别和盐敏感性血压的诊断中
- 申请号：EP13777937.7 申请日：2013-04-22
- 公开(公告)号：EP2839281A1 公开(公告)日：2015-02-25
- 发明人： FELDER, Robin A. , CAREY, Robert M. , JONES, John E. , JOSE, Pedro A. , WILLIAMS, Scott M.
- 申请人： University of Virginia Patent Foundation , Felder, Robin A. , Carey, Robert M. , Jones, John E. , Jose, Pedro A. , Williams, Scott M.
- 申请人地址： 250 West Main Street, Suite 300 Charlottesville, VA 22902 US
- 专利权人： University of Virginia Patent Foundation,Felder, Robin A.,Carey, Robert M.,Jones, John E.,Jose, Pedro A.,Williams, Scott M.
- 当前专利权人： University of Virginia Patent Foundation,Felder, Robin A.,Carey, Robert M.,Jones, John E.,Jose, Pedro A.,Williams, Scott M.
- 当前专利权人地址： 250 West Main Street, Suite 300 Charlottesville, VA 22902 US
- 代理机构： Main, Malcolm Charles
- 优先权： US201261636576P 20120420
- 国际公布： WO2013159085 20131024
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12Q1/68 ; C12N15/11
摘要：
It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na
+ (10 mmol/d) and 7 days high Na
+ (300 mmol/d) intake. Salt sensitivity was defined as a ≥7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P
摘要（中）：
+ (10 mmol/d) and 7 days high Na
+ (300 mmol/d) intake. Salt sensitivity was defined as a ≥7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P
这是确定性的开采无论的SNP在SLC4A5与血压（BP）的盐敏感性相关联。 消耗+等热量饮食常数与7天的Na低（10毫摩尔/天）和7天高的Na +（300毫摩尔/ D）进一个随机的顺序的受试者。 盐敏感性什么定义为平均动脉压（MAP）一个≧7毫米汞柱增加。 在17个候选基因35点的多态性进行测定。 协会盐敏感性分析发现三种变体就与盐敏感性，两个SLC4A5关联（rs7571842，rs10177833; P <0.001），和一个在GRK4（rs1801058，P = 0.020）。 在血压响应于盐摄入量的变化似非而是的变化因此发现与一个SNP为DRD2（rs6276）相关联。 总之，SLC4A5变体强烈BP的盐敏感性在高加索人相关联和DRD2 SNP是用于向食盐摄入量反常响应的标记。