基本信息:
- 专利标题： BENZODIOXANES FOR INHIBITING LEUKOTRIENE PRODUCTION
- 专利标题（中）：BENZODIOXANE ZUR HEMMUNG DER LEUKOTRIENPRODUKTION
- 申请号：EP13712002.8 申请日：2013-03-05
- 公开(公告)号：EP2822942A1 公开(公告)日：2015-01-14
- 发明人： BRUNETTE, Steven, Richard , ABEYWARDANE, Asitha , BURKE, Michael, J. , KAPADIA, Suresh, R. , KIRRANE, Thomas, Martin, Jr. , NETHERTON, Matthew, Russell , RAZAVI, Hossein , RODRIGUEZ, Sonia , SAHA, Anjan , SIBLAY, Robert , SMITH KEENAN, Lana, Louise , TAKAHASHI, Hidenori , TURNER, Michael, Robert , WU, Jiang-Ping , YOUNG, Erick, Richard, Roush , ZHANG, Qiang , ZHANG, Qing , ZINDELL, Renee, M.
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Binger Strasse 173 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim DE
- 代理机构： Simon, Elke Anna Maria
- 优先权： US201261607136P 20120306
- 国际公布： WO2013134226 20130912
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; A61K31/357 ; C07D319/20 ; C07D405/10 ; C07D405/12 ; C07D487/10 ; A61P9/00
摘要：
The present invention relates to compounds of formula (I) wherein R
1 to R
3 , A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A
4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要（中）：
1 to R
3 , A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A
4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
本发明涉及式（I）的化合物：其中R1至R3，A，X和n如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
公开/授权文献:
- EP2822942B1 BENZODIOXANES FOR INHIBITING LEUKOTRIENE PRODUCTION 公开/授权日：2017-05-10
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D405/00 | 杂环化合物，含有1个或多个以氧原子作为仅有的杂环原子的环，且含有1个或多个以氮原子作为仅有的杂环原子的环 |
| --------C07D405/14 | .含3个或更多个杂环 |